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Alaska Blind Child Discovery |
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A
cooperative, charitable research project to vision screen every preschool
Alaskan |
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ATS-4 (Atropine Dose) |
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ABCD History |
OBJECTIVE:
To compare daily atropine to weekend atropine as prescribed treatments for
moderate amblyopia in children younger than 7 years. DESIGN: Prospective,
randomized multicenter clinical trial (30 sites). PARTICIPANTS: One
hundred sixty-eight children younger than 7 years with amblyopia in the
range of 20/40 to 20/80 associated with strabismus, anisometropia,
or both. INTERVENTION: Randomization either to daily atropine or to weekend
atropine for 4 months. Partial responders were continued on the randomized
treatment until no further improvement was noted. MAIN OUTCOME MEASURE:
Visual acuity (VA) in the amblyopic eye after 4 months. RESULTS: The improvement
in VA of the amblyopic eye from baseline to 4 months averaged 2.3 lines
in each group. The VA of the amblyopic eye at study completion was either
(1) at least 20/25 or (2) better than or equal to that of the sound eye
in 39 children (47%) in the daily group and 45 children (53%) in the weekend
group. The VA of the sound eye at the end of follow-up was reduced by 2
lines in one patient in each group. Stereoacuity outcomes were similar in
the 2 groups. CONCLUSIONS: Weekend atropine provides
an improvement in VA of a magnitude similar to that of the improvement provided
by daily atropine in treating moderate amblyopia in children 3 to 7 years
old. This article contains additional online-only material available
at http://www.ophsource.com/periodicals/ophtha.[1] 1. PEDIG, Repka MX, Cotter SA, Beck RW, Kraker RT, Birch EE, Everett DF, Hertle RW, Holmes JM, Quinn GE, et al: A randomized trial of atropine regimens for treatment of moderate amblyopia in children. Ophthalmology 2004, 111:2076-2085. |
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Kids Eye Disorders |
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Amblyopia |
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Vision Screening |
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Issues |
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ABCD Clinics |
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